Article Navigation
Journal Article
Get access
, Iwan Paolucci Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center , Houston, Texas , USA Search for other works by this author on: Oxford Academic Jessica Albuquerque Marques Silva Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center , Houston, Texas , USA Search for other works by this author on: Oxford Academic Yuan-Mao Lin Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center , Houston, Texas , USA Search for other works by this author on: Oxford Academic Gregor Laimer Department of Radiology, Interventional Oncology/Stereotaxy and Robotics, Medical University of Innsbruck , Innsbruck , Austria Search for other works by this author on: Oxford Academic Valentina Cignini Department of Surgical Sciences, University of Turin , Turin , Italy Search for other works by this author on: Oxford Academic Francesca Menchini Department of Surgical Sciences, University of Turin , Turin , Italy Search for other works by this author on: Oxford Academic Marcio Meira Department of Radiology, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo , São Paulo , Brazil Search for other works by this author on: Oxford Academic Alexander Shieh Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center , Houston, Texas , USA Search for other works by this author on: Oxford Academic Caleb O’Connor Department of Imaging Physics, The University of Texas MD Anderson Cancer Center , Houston, Texas , USA Search for other works by this author on: Oxford Academic Kyle A Jones Department of Imaging Physics, The University of Texas MD Anderson Cancer Center , Houston, Texas , USA Search for other works by this author on: Oxford Academic
https://orcid.org/0000-0002-9393-3015 , Carlo Gazzera Department of Diagnostic Imaging and Interventional Radiology, Città della Salute e della Scienza , Turin , Italy Search for other works by this author on: Oxford Academic Paolo Fonio Department of Diagnostic Imaging and Interventional Radiology, Città della Salute e della Scienza , Turin , Italy Search for other works by this author on: Oxford Academic Kristy K Brock Department of Imaging Physics, The University of Texas MD Anderson Cancer Center , Houston, Texas , USA Search for other works by this author on: Oxford Academic Marco Calandri Department of Diagnostic Imaging and Interventional Radiology, Città della Salute e della Scienza , Turin , Italy Search for other works by this author on: Oxford Academic Marcos Menezes Department of Radiology, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo , São Paulo , Brazil Search for other works by this author on: Oxford Academic Reto Bale Department of Radiology, Interventional Oncology/Stereotaxy and Robotics, Medical University of Innsbruck , Innsbruck , Austria Search for other works by this author on: Oxford Academic Bruno C Odisio Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center , Houston, Texas , USA Correspondence to: Bruno C. Odisio, Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, 1400 Pressler St. | Unit 1471, Houston, Texas, 77030, USA (e-mail: bcodisio@mdanderson.org) Search for other works by this author on: Oxford Academic
British Journal of Surgery, Volume 111, Issue 9, September 2024, znae165, https://doi.org/10.1093/bjs/znae165
Published:
30 August 2024
Article history
Received:
23 February 2024
Revision received:
15 May 2024
Accepted:
17 June 2024
Published:
30 August 2024
- Views
- Article contents
- Figures & tables
- Video
- Audio
- Supplementary Data
-
Cite
Cite
Iwan Paolucci, Jessica Albuquerque Marques Silva, Yuan-Mao Lin, Gregor Laimer, Valentina Cignini, Francesca Menchini, Marcio Meira, Alexander Shieh, Caleb O’Connor, Kyle A Jones, Carlo Gazzera, Paolo Fonio, Kristy K Brock, Marco Calandri, Marcos Menezes, Reto Bale, Bruno C Odisio, Identification of A0 minimum ablative margins for colorectal liver metastases: multicentre, retrospective study using deformable CT registration and artificial intelligence-based autosegmentation, British Journal of Surgery, Volume 111, Issue 9, September 2024, znae165, https://doi.org/10.1093/bjs/znae165
Close
Search
Close
Search
Advanced Search
Search Menu
Abstract
Background
Several ablation confirmation software methods for minimum ablative margin assessment have recently been developed to improve local outcomes for patients undergoing thermal ablation of colorectal liver metastases. Previous assessments were limited to single institutions mostly at the place of development. The aim of this study was to validate the previously identified 5 mm minimum ablative margin (A0) using autosegmentation and biomechanical deformable image registration in a multi-institutional setting.
Methods
This was a multicentre, retrospective study including patients with colorectal liver metastases undergoing CT- or ultrasound-guided microwave or radiofrequency ablation during 2009–2022, reporting 3-year local disease progression (residual unablated tumour or local tumour progression) rates by minimum ablative margin across all institutions and identifying an intraprocedural contrast-enhanced CT-based minimum ablative margin associated with a 3-year local disease progression rate of less than 1%.
Results
A total of 400 ablated colorectal liver metastases (median diameter of 1.5 cm) in 243 patients (145 men; median age of 62 [interquartile range 54–70] years) were evaluated, with a median follow-up of 26 (interquartile range 17–40) months. A total of 119 (48.9%) patients with 186 (46.5%) colorectal liver metastases were from international institutions B, C, and D that were not involved in the software development. Three-year local disease progression rates for 0 mm, >0 and <5 mm, and 5 mm or larger minimum ablative margins were 79%, 15%, and 0% respectively for institution A (where the software was developed) and 34%, 19%, and 2% respectively for institutions B, C, and D combined. Local disease progression risk decreased to less than 1% with an intraprocedurally confirmed minimum ablative margin greater than 4.6 mm.
Conclusion
A minimum ablative margin of 5 mm or larger demonstrates optimal local oncological outcomes. It is proposed that an intraprocedural minimum ablative margin of 5 mm or larger, confirmed using biomechanical deformable image registration, serves as the A0 for colorectal liver metastasis thermal ablation.
© The Author(s) 2024. Published by Oxford University Press on behalf of BJS Foundation Ltd. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.
This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/pages/standard-publication-reuse-rights)
Subject
Experimental Science Hepato-Pancreato-Biliary Surgery
Issue Section:
Original Article
You do not currently have access to this article.
Download all slides
Sign in
Get help with access
-
BJS members
Sign in through society site
Personal account
- Sign in with email/username & password
- Get email alerts
- Save searches
- Purchase content
- Activate your purchase/trial code
- Add your ORCID iD
Sign in Register
Institutional access
- Sign in with a library card
- Sign in with username/password
- Recommend to your librarian
Sign in through your institution
Sign in through your institution
Institutional account management
Sign in as administrator
Get help with access
Institutional access
Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:
IP based access
Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.
Sign in through your institution
Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.
- Click Sign in through your institution.
- Select your institution from the list provided, which will take you to your institution's website to sign in.
- When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
- Following successful sign in, you will be returned to Oxford Academic.
If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.
Sign in with a library card
Enter your library card number to sign in. If you cannot sign in, please contact your librarian.
Society Members
Society member access to a journal is achieved in one of the following ways:
Sign in through society site
Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:
- Click Sign in through society site.
- When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
- Following successful sign in, you will be returned to Oxford Academic.
If you do not have a society account or have forgotten your username or password, please contact your society.
Sign in using a personal account
Some societies use Oxford Academic personal accounts to provide access to their members. See below.
Personal account
A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.
Some societies use Oxford Academic personal accounts to provide access to their members.
Viewing your signed in accounts
Click the account icon in the top right to:
- View your signed in personal account and access account management features.
- View the institutional accounts that are providing access.
Signed in but can't access content
Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.
Institutional account management
For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.
Purchase
Subscription prices and ordering for this journal
Purchasing options for books and journals across Oxford Academic
Short-term Access
To purchase short-term access, please sign in to your personal account above.
Don't already have a personal account? Register
Identification of A0 minimum ablative margins for colorectal liver metastases: multicentre, retrospective study using deformable CT registration and artificial intelligence-based autosegmentation - 24 Hours access
EUR €51.00
GBP £44.00
USD $55.00
Rental
This article is also available for rental through DeepDyve.
Advertisem*nt intended for healthcare professionals
Citations
Views
Altmetric
More metrics information
Metrics
Total Views 0
0 Pageviews
0 PDF Downloads
Since 8/31/2024
Citations
Powered by Dimensions
Altmetrics
Email alerts
Article activity alert
Advance article alerts
New issue alert
Subject alert
Receive exclusive offers and updates from Oxford Academic
See also
-
Companion Article
- Curative-intent ablation margins (A0) for colorectal liver metastasis: more burning questions
Citing articles via
Google Scholar
-
Most Read
-
Most Cited
More from Oxford Academic
Medicine and Health
Surgery
Books
Journals
Advertisem*nt intended for healthcare professionals
